Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications

Full Metadata

Overview

Title
Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications
Contributors
Ho, Don N (creator)
Sun, Shouheng (Director)
Kim, Eunsuk (Reader)
Webster, Thomas (Reader)
Brown University. Chemistry (sponsor)
Doi
10.7301/Z0BP0148
Copyright Date
2013
Abstract
Theranostics is the ability to diagnose with greater detail to disease properties and tailor specialized therapeutic regiments to a patient's unique case. Advancements in nanoparticle synthesis for controlled material properties and further functionalization make the nano-scale materials promising candidates as a theranostic platform for predictive medicine, early detection, targeted therapy, and diagnostic monitoring. Here we examine iron oxide, gold-silver alloy, and gold-iron oxide dumbbell-like heterostructure nanoparticles for their combined diagnostic and therapeutic application.<br/> Iron oxide nanoparticles are used clinically as MRI contrast agents and also provide a platform for functionalization and further application of their magnetic properties. We examine the targeting of iron oxide to tumor vasculature using the tumstatin peptide in a three-dimensional in vitro tumor model and observe the therapeutic heating abilities in an alternating magnetic field.<br/> Surface enhanced fluorescence from nano-sized metal materials occurs through near-field coupling of the local electromagnetic field. We focus on controlling the surface plasmon resonance of AuAg alloy nanoparticles (AuAgNP) with a tunable method for transferring energy with fluorescent proteins. We examine the synthesis, surface modification, and localization of AuAgNPs to protein targets. We use fluorescein isothiocyanate as a model fluorophore to measure optimal energy transfer conditions. We examine green fluorescent protein as a target protein fluorophore for the protein model. Determination of alloy content, distance control, and targeting abilities for enhanced fluorescence can optimize current fluorescence imaging techniques and quantitative assays with greater sensitivity. <br/> Advanced hetero-structure nanoparticles offer added material properties and chemical functionalization over single component nanoparticles. We examine the controlled diagnostic and therapeutic capabilities of the dumbbell-like hetero-structure of gold-iron oxide nanoparticles for targeted in vivo pancreatic cancer MRI enhancement.
Keywords
iron oxide
theranositcs
optical
magnetic
mri
drug delivery
molecular imaging
imaging
Nanoparticles
Nanomedicine
Gold
Silver
Ferric oxide
Alloys
Heterostructures
Midwest Research Institute (Kansas City, Mo.)
Drug delivery systems
Magnetic resonance imaging
Notes
Thesis (Ph.D. -- Brown University (2013)
Extent
xiv, 176 p.

Citation

Ho, Don N., "Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications" (2013). Chemistry Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.7301/Z0BP0148

Relations

Collection: