- Title Information
- Title
- Autism Spectrum Disorder: Comorbidity and Etiology
- Name:
Personal
- Name Part
- Viscidi, Emma W
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
- 2014
- Physical Description
- Extent
- x, 136 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D. -- Brown University (2014)
- Name:
Personal
- Name Part
- Triche, Elizabeth
- Role
- Role Term:
Text
- Director
- Name:
Personal
- Name Part
- Buka, Stephen
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Morrow, Eric
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Spence, Sarah
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. BIOMED: Epidemiology
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is estimated to affect as many as 1 in 88 children. Epilepsy is a common comorbid condition in persons with ASD, but little is known about the prevalence of the disorder or clinical characteristics of individuals with ASD and epilepsy. While the cause of ASD is unknown, there is evidence that prenatal factors may play an etiological role.
Objectives: To examine clinical characteristics of children with ASD and epilepsy and the association between prenatal risk factors and ASD.
Methods: The association between epilepsy and ASD and prenatal risk factors for ASD were studied using several large samples. Participants were drawn from genetic collaborative datasets and population-based samples, including the Collaborative Perinatal Project (CPP). Multivariate regression modeling was used to control for confounding, in particular confounding by cognitive functioning.
Results: Various clinical correlates of ASD and epilepsy were identified. Low IQ was found to be the best predictor of epilepsy in children with ASD. Children with epilepsy had more autism symptoms and maladaptive behaviors than children with ASD alone. Several prenatal characteristics that increase risk of ASD were identified including older maternal and paternal age at birth, bleeding during pregnancy, and edema. Intellectual disability was found to be a mild confounder of the association between prenatal risk factors and ASD.
Conclusions: In a large sample of children with ASD, low cognitive ability emerged as a strong independent predictor of epilepsy. Children with ASD and epilepsy showed greater impairment than children with ASD without epilepsy, and this was mostly explained by the lower IQ of children with epilepsy. Prior associations between prenatal factors and autism were confirmed in a large population-based cohort study. This study paves the way for future research on ASD in the Collaborative Perinatal Project (CPP).
- Subject
- Topic
- intellectual disability
- Subject
- Topic
- prenatal
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/822484")
- Topic
- Autism
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/914183")
- Topic
- Epilepsy
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20141006
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z0GF0RV6
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations