- Title Information
- Title
- The Effect of Confinement on Neutrophil Force Generation
- Name:
Personal
- Name Part
- Toyjanova, Jennet
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
- 2015
- Physical Description
- Extent
- xxii, 123 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D. -- Brown University (2015)
- Name:
Personal
- Name Part
- Franck, Christian
- Role
- Role Term:
Text
- Director
- Name:
Personal
- Name Part
- Bower, Allan
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Hammer, Daniel
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Kim, Kyung-Suk
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Reichner, Jonathan
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. ENGINEERING: Mechanics of Solids
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- Generation of forces is essential for the migration of neutrophils to the sites of infection or injury. The mechanical properties and local confinement of the surrounding microenvironment play a significant role in regulating these forces. However, it is challenging to decouple each of these features experimentally without inherently changing the microstructure of the cell environment. Presented here is an experimental method that is used to isolate confinement and substrate stiffness as single variables in the neutrophil environment. Using a combination of fast iterative digital volume correlation and traction force microscopy techniques, this dissertation demonstrates that neutrophils induce finite displacements on their surroundings. Furthermore, the findings show that neutrophil-generated forces are highly affected by confinement and stiffness of their microenvironment.
- Subject
- Topic
- cell mechanics
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/850266")
- Topic
- Cells--Mechanical properties
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20150601
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z0TM78GZ
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations