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Year:: 2015
Contributor:: Xu, Anna (creator); Kerr, Catherine (advisor); Brown University. Undergraduate Teaching and Research Award (research program)
Genre:: posters
Subject:: Irritable colon; Somatization disorder
Extent:: 1 poster
DOI: https://doi.org/10.26300/rca0-p006

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Abstract:: Irritable bowel syndrome (IBS) is a chronic pain disorder characterized by chronic altered bowel activity with no known organic cause, resistance to any one form of treatment and heterogeneity in experiences of symptoms. Our previous study used behavioral measures of somatization and resting state fMRI data from 26 female adult patients with IBS and found evidence suggesting that somatization behavioral measures correlate with functional connectivity of insula to the anterior cingulate cortex (ACC). We now attempt to extend these earlier findings to analyze, through a graph theory perspective, what network properties characterize the insula and ACC in high somatizers compared to low somatizers. Using CONN Toolbox v15, we found high node degree in the anterior insular cortex (AIC) in both groups of somatizers, but only low somatizers showed high node degree in the posterior insular cortex (PIC) when we analyzed the AIC, PIC and ACC. A high node degree indicates the crucial role of a node in information integration in a network, and our results suggests the existence of the PIC as a potential hub to be a defining feature characterizing low somatizers.

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Xu, Anna, "Role of posterior insula in characterizing somatization: graph theory analysis of pain processing neural substrates in chronic pain " (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/rca0-p006

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Summer Research Symposium

Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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Role of posterior insula in characterizing somatization: graph theory analysis of pain processing neural substrates in chronic pain