<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" ID="Xu" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/mods/v3/mods-3-6.xsd">
<mods:titleInfo>
<mods:title>Role of posterior insula in characterizing somatization</mods:title>
<mods:subTitle>graph theory analysis of pain processing neural substrates in chronic
pain</mods:subTitle>
</mods:titleInfo>
<mods:name type="personal">
<mods:namePart>Xu, Anna</mods:namePart>
<mods:role>
<mods:roleTerm type="text">creator</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart>Kerr, Catherine</mods:namePart>
<mods:role>
<mods:roleTerm type="text">advisor</mods:roleTerm>
</mods:role>
<mods:affiliation>Brown University. Department of Family Medicine</mods:affiliation>
</mods:name>
<mods:name type="corporate">
<mods:namePart>Brown University. Undergraduate Teaching and Research Award</mods:namePart>
<mods:role>
<mods:roleTerm type="text">research program</mods:roleTerm>
</mods:role>
</mods:name>
<mods:typeOfResource>still image</mods:typeOfResource>
<mods:genre authority="aat">posters</mods:genre>
<mods:originInfo>
<mods:place>
<mods:placeTerm type="text">Providence</mods:placeTerm>
</mods:place>
<mods:publisher>Brown University</mods:publisher>
<mods:dateCreated encoding="w3cdtf">2015-08-07</mods:dateCreated>
</mods:originInfo>
<mods:physicalDescription>
<mods:extent>1 poster</mods:extent>
<mods:digitalOrigin>reformatted digital</mods:digitalOrigin>
</mods:physicalDescription>
<mods:abstract>Irritable bowel syndrome (IBS) is a chronic pain disorder characterized by
chronic altered bowel activity with no known organic cause, resistance to any one form of
treatment and heterogeneity in experiences of symptoms. Our previous study used behavioral
measures of somatization and resting state fMRI data from 26 female adult patients with IBS
and found evidence suggesting that somatization behavioral measures correlate with
functional connectivity of insula to the anterior cingulate cortex (ACC). We now attempt to
extend these earlier findings to analyze, through a graph theory perspective, what network
properties characterize the insula and ACC in high somatizers compared to low somatizers.
Using CONN Toolbox v15, we found high node degree in the anterior insular cortex (AIC) in
both groups of somatizers, but only low somatizers showed high node degree in the posterior
insular cortex (PIC) when we analyzed the AIC, PIC and ACC. A high node degree indicates the
crucial role of a node in information integration in a network, and our results suggests the
existence of the PIC as a potential hub to be a defining feature characterizing low
somatizers.</mods:abstract>
<mods:subject authority="lcsh">
<mods:topic>Irritable colon</mods:topic>
</mods:subject>
<mods:subject authority="lcsh">
<mods:topic>Somatization disorder</mods:topic>
</mods:subject>
<mods:identifier xmlns:xlink="http://www.w3.org/1999/xlink" type="doi">10.26300/rca0-p006</mods:identifier></mods:mods>