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A mathematically rigorous algorithm for long-range haplotype phasing


Human beings are diploid organisms, and it is of great medical and biological interest to accurately obtain the sequences of each chromosome as it aids in the identification of any mutations that correlate highly with the incidence of diseases. The current cutting-edge sequencing technologies, however, leave this haplotype phasing ambiguous - we know two variants exist at a position, but not which strand it belongs to. I implement and examine an APFA-based long-range haplotype phasing algorithm capable of resolving these ambiguities through the use of sophisticated statistical inference techniques.


Crisanto, Samuel Angelo, "A mathematically rigorous algorithm for long-range haplotype phasing" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library.



  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …