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The impact of febrile temperature on alloreactive immune responses


Cellular immunotherapy is a type of treatment available to cancer patients where the immune system is utilized to combat tumors. In a previous clinical trial, patients who were given this treatment were infused with haploidentical CD3+ cells at 1-2x10^8 CD3+ cells/kg. Over half of these patients developed major responses with all of them developing a fever of 104°F. In order to determine what specific variables made some responses more effective than others, we looked at different factors that could be affecting them-one of them being fever. In previous studies, fever has been found to incur beneficial effects to patients and so we focused on testing whether fever could have a positive influence on alloreactive immune responses. In order to investigate this, we used mixed lymphocyte cultures (MLCs) incubated in duplicate at 37°C and 40°C for varying incubation periods with a few different stimulators. We measured cell proliferation and cytotoxicity to determine whether fever proved to enhance the immune response. Preliminary results show that exposure of cells to 40°C seems to inhibit the immune response by perhaps killing off T lymphocytes.


Zheng, Jessica, "The impact of febrile temperature on alloreactive immune responses" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library.



  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …