<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" ID="Jamieson" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/mods/v3/mods-3-6.xsd">
<mods:titleInfo>
<mods:title>Achieving bacteriostasis using diamide inhibitors of bacterial
GlcNAcases</mods:title>
</mods:titleInfo>
<mods:name type="personal">
<mods:namePart>Jamieson, Mitchell</mods:namePart>
<mods:role>
<mods:roleTerm type="text">creator</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart>Basu, Amit</mods:namePart>
<mods:role>
<mods:roleTerm type="text">advisor</mods:roleTerm>
</mods:role>
<mods:affiliation>Brown University. Department of Chemistry</mods:affiliation>
</mods:name>
<mods:name type="corporate">
<mods:namePart>Brown University. LINK Award</mods:namePart>
<mods:role>
<mods:roleTerm type="text">research program</mods:roleTerm>
</mods:role>
</mods:name>
<mods:typeOfResource>still image</mods:typeOfResource>
<mods:genre authority="aat">posters</mods:genre>
<mods:originInfo>
<mods:place>
<mods:placeTerm type="text">Providence</mods:placeTerm>
</mods:place>
<mods:publisher>Brown University</mods:publisher>
<mods:dateCreated encoding="w3cdtf">2015-08-07</mods:dateCreated>
</mods:originInfo>
<mods:physicalDescription>
<mods:extent>1 poster</mods:extent>
<mods:digitalOrigin>reformatted digital</mods:digitalOrigin>
</mods:physicalDescription>
<mods:abstract>Last year, the World Health Organization classified antimicrobial resistance as a
"serious, worldwide threat to public health." Newly developed antibiotics must therefore
circumvent the known mechanisms of bacterial resistance for better efficacy. The Basu
Laboratory has discovered a new class of small molecules that inhibit bacterial cell wall
recycling and remodeling enzymes that act on the invariable glycan backbone of the
peptidoglycan heteropolymer. Several of these compounds have demonstrated bacteriostatic
activity against Bacillus subtilis. The most potent inhibitors are dipeptides that were
synthesized using the Ugi multicomponent condensation reaction. Resazurin whole cell assays
have proven successful, and preliminary isothermal titration calorimetry experiments
utilizing the enzyme target LytG (exo-acting GlcNAcase) are promising. With a large compound
library in its third generation, we aim to improve the potency of these inhibitors through
determination of which moieties hinder bacterial growth most.</mods:abstract>
<mods:subject authority="lcsh">
<mods:topic>Drug resistance in microorganisms</mods:topic>
</mods:subject>
<mods:subject authority="lcsh">
<mods:topic>Peptidoglycans</mods:topic>
</mods:subject>
<mods:subject authority="lcsh">
<mods:topic>Resazurin</mods:topic>
</mods:subject>
<mods:identifier xmlns:xlink="http://www.w3.org/1999/xlink" type="doi">10.26300/kzze-wy65</mods:identifier></mods:mods>