<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" ID="Jamieson" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/mods/v3/mods-3-6.xsd">
  <mods:titleInfo>
    <mods:title>Achieving bacteriostasis using diamide inhibitors of bacterial

            GlcNAcases</mods:title>
  </mods:titleInfo>
  <mods:name type="personal">
    <mods:namePart>Jamieson, Mitchell</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">creator</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:name type="personal">
    <mods:namePart>Basu, Amit</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">advisor</mods:roleTerm>
    </mods:role>
    <mods:affiliation>Brown University. Department of Chemistry</mods:affiliation>
  </mods:name>
  <mods:name type="corporate">
    <mods:namePart>Brown University. LINK Award</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">research program</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:typeOfResource>still image</mods:typeOfResource>
  <mods:genre authority="aat">posters</mods:genre>
  <mods:originInfo>
    <mods:place>
      <mods:placeTerm type="text">Providence</mods:placeTerm>
    </mods:place>
    <mods:publisher>Brown University</mods:publisher>
    <mods:dateCreated encoding="w3cdtf">2015-08-07</mods:dateCreated>
  </mods:originInfo>
  <mods:physicalDescription>
    <mods:extent>1 poster</mods:extent>
    <mods:digitalOrigin>reformatted digital</mods:digitalOrigin>
  </mods:physicalDescription>
  <mods:abstract>Last year, the World Health Organization classified antimicrobial resistance as a

        "serious, worldwide threat to public health." Newly developed antibiotics must therefore

        circumvent the known mechanisms of bacterial resistance for better efficacy. The Basu

        Laboratory has discovered a new class of small molecules that inhibit bacterial cell wall

        recycling and remodeling enzymes that act on the invariable glycan backbone of the

        peptidoglycan heteropolymer. Several of these compounds have demonstrated bacteriostatic

        activity against Bacillus subtilis. The most potent inhibitors are dipeptides that were

        synthesized using the Ugi multicomponent condensation reaction. Resazurin whole cell assays

        have proven successful, and preliminary isothermal titration calorimetry experiments

        utilizing the enzyme target LytG (exo-acting GlcNAcase) are promising. With a large compound

        library in its third generation, we aim to improve the potency of these inhibitors through

        determination of which moieties hinder bacterial growth most.</mods:abstract>
  <mods:subject authority="lcsh">
    <mods:topic>Drug resistance in microorganisms</mods:topic>
  </mods:subject>
  <mods:subject authority="lcsh">
    <mods:topic>Peptidoglycans</mods:topic>
  </mods:subject>
  <mods:subject authority="lcsh">
    <mods:topic>Resazurin</mods:topic>
  </mods:subject>
<mods:identifier xmlns:xlink="http://www.w3.org/1999/xlink" type="doi">10.26300/kzze-wy65</mods:identifier></mods:mods>