Title Information
Title
Identical by descent tracts in unphased genotypes
Name: Personal
Name Part
Seidman, Daniel
Role
Role Term: Text
creator
Name: Personal
Name Part
Istrail, Sorin
Role
Role Term: Text
advisor
affiliation
Brown University. Department of Computer Science
Name: Corporate
Name Part
Brown University. Undergraduate Teaching and Research Award
Role
Role Term: Text
research program
Type of Resource
still image
Genre (aat)
posters
Origin Information
Place
Place Term: Text
Providence
Publisher
Brown University
Date Created (encoding="w3cdtf")
2015-08-07
Physical Description
Extent
1 poster
digitalOrigin
reformatted digital
Abstract
I am designing a program to be able to identify Identical by Descent (IBD) tracts in unphased genotypes. In many cases, when genomes are sequenced, it can be difficult to localize which fragments of known sequence belong on which of a set of complimentary chromosomes, and as such, sequence data can be ambiguous. Usually this ambiguity is resolved through phasing, where the each piece of known sequence is localized to one particular complimentary chromosome via statistical estimates and knowledge of relationships between sequences. Once done, it is possible to determine if two portions of DNA sequence in two separate chromosomes share a common ancestral origin. However, the common ancestral origin information (a.k.a. Identical By Descent) would be very useful for the statistics involved in phasing, thus the ability to determine the tracts of Identical by Descent DNA sequence would assist the statistical accuracy of the phasing if it could be done first. That is what my program currently aims to accomplish, as efficiently in both time and memory possible.
Subject (LCSH)
Topic
Nucleotide sequence
Subject (LCSH)
Topic
Computational biology
Subject (Local)
Topic
Identical by descent
Identifier: DOI
10.26300/zsqr-4b69