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Ovarian transplants in wild type and biglycan/decorin knockout mice

Description

Abstract:
One third of preterm births are caused by preterm premature rupture of fetal membranes (PPROM). A genetic cause of PPROM is the connective tissue disorder Elhers-Danlos Syndrome. A subtype of this disorder is caused by the abnormal secretion of the extracellular matrix proteoglycans biglycan and decorin. We developed a biglycan/decorin null mutant mouse as a model of genetically induced preterm birth and perinatal loss. In order to determine the contribution of maternal (uterus) versus pup (fetal membranes) genotype, we performed embryo and ovarian transfers in our biglycan/decorin null mutant and wild type (WT) females and evaluated the females based on the parameters of pregnancy duration, labor duration, and presence of dystocia.

Citation

Perecki, Natalia, "Ovarian transplants in wild type and biglycan/decorin knockout mice" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/mkcz-9070

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Collection:

  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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