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Enzyme engineering to change the activity of a diabetes drug target: PTP1B

Description

Abstract:
PTP1B is a protein tyrosine phosphatase (Fig 1). Excess activation of this protein limits uptake of glucose [1]. A number of different loops characterize PTP1B. The WPD loop (res 178-187) is one that plays a central role in catalysis. When substrate binds, it brings Asp 181 closer to the active site to facilitate proton transfers (Fig 2) [2]. We hypothesize that introducing more flexibility into the WPD loop will allow PTP1B to be a more efficient catalyst

Citation

Wei, Xingyu, "Enzyme engineering to change the activity of a diabetes drug target: PTP1B" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/kppj-kh93

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Collection:

  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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