PTP1B is a protein tyrosine phosphatase (Fig 1). Excess activation of this protein limits uptake of glucose . A number of different loops characterize PTP1B. The WPD loop (res 178-187) is one that plays a central role in catalysis. When substrate binds, it brings Asp 181 closer to the active site to facilitate proton transfers (Fig 2) . We hypothesize that introducing more flexibility into the WPD loop will allow PTP1B to be a more efficient catalyst
"Enzyme engineering to change the activity of a diabetes drug target: PTP1B"
Summer Research Symposium.
Brown Digital Repository. Brown University Library.
Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …