Exploring triphenylene ethynylene structures as MALDI matrices

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Abstract:
MALDI continues to be a useful method of mass spectrometry for a wide range of biological molecules. This poster explores the use of several preliminary triphenylene ethynylene (TPEE) structures that may be useful as matrices in MALDI spectrometry. Three electron-donating TPEEs were synthesized and analyzed and two electron-withdrawing TPEEs were synthesized and compared to TCNQ. One of the electron-donating matrices and one of the electron-withdrawing matrices showed significant promise as effective MALDI matrices, demonstrating minimal fragmentation, low matrix peaks, and high analyte signal strength.

Citation

Mayans, David, "Exploring triphenylene ethynylene structures as MALDI matrices" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/gy86-3475

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    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …

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