Extracellular field potential recordings in hippocampal CA1 and dorsal horn of wild type and TRPV1-Cre x ChR2 mice

Description

Abstract:
TRPV1 is a heat- and capsaicin-activated receptor expressed on C-fibers, nociceptors that carry pain information from the periphery to the brain. Channelrhodopsin 2 (ChR2) is a blue light-activated ion channel not normally expressed in animals. In mice genetically engineered to express ChR2 in Trpv1-expressing C fiber afferents, blue light stimulation of the paw activates these pain fibers, mimicking a painful stimulus.

Citation

Polynice, Shahena, "Extracellular field potential recordings in hippocampal CA1 and dorsal horn of wild type and TRPV1-Cre x ChR2 mice" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/8c7m-ha62

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    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …

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