- Title Information
- Title
- Testing altered learning in the D2 corticostriatal pathway with antipsychotic
exposure
- Name:
Personal
- Name Part
- Hill, Melissa
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Warwick, Hunter
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Vierling-Claassen, Nathan
- Role
- Role Term:
Text
- advisor
- affiliation
- Brown University. Department of Neuroscience
- Name:
Personal
- Name Part
- Frank, Michael
- Role
- Role Term:
Text
- advisor
- affiliation
- Brown University. Department of Cognitive, Linguistic and Psychological
Sciences
- Name:
Personal
- Name Part
- Moore, Christopher
- Role
- Role Term:
Text
- advisor
- affiliation
- Brown University. Department of Neuroscience
- Name:
Personal
- Name Part
- Bath, Kevin
- Role
- Role Term:
Text
- advisor
- Name:
Corporate
- Name Part
- Brown University. Undergraduate Teaching and Research Award
- Role
- Role Term:
Text
- research program
- Type of Resource
- still image
- Genre (aat)
- posters
- Origin Information
- Place
- Place Term:
Text
- Providence
- Publisher
- Brown University
- Date Created
(keyDate="yes", encoding="w3cdtf")
- 2015-08-07
- Physical Description
- Extent
- 1 poster
- digitalOrigin
- reformatted digital
- Language
- Language Term
- eng
- Abstract
- Antipsychotic medications can be successful in alleviating the positive symptoms
of psychosis, such as delusions and hallucinations, but are unsuccessful at treating the
negative symptoms of schizophrenia, including emotional flatness and lack of motivation.
Antipsychotic medications, such as Haloperidol, are Dopamine D2 receptor blockers and are
involved in learning, motivation, reward, movement and coordination. There is evidence that
a blockade of D2 receptors can bias individuals to learn more from \"negative\" outcomes,
and that this can be due to an altered balance of receptor activation in regions of the
cortico-striatal pathway responsible for reward processing. In other words, certain pathways
in the brain become strengthened such that there is a bias toward learning from negative
outcomes and omission of expected rewards. Our prediction is that a long-term D2 blockade,
such as during antipsychotic treatment with Haloperidol, may generate increased learning
from negative outcomes and suppressed motivation, possibly contributing to lack of efficacy
in the treatment of negative symptoms of schizophrenia.
- Subject (LCSH)
- Topic
- Neurosciences
- Subject (LCSH)
- Topic
- Antipsychotic drugs
- Subject (LCSH)
- Topic
- Schizophrenia
- Subject (LCSH)
- Topic
- Dopamine
- Subject (Local)
- Topic
- Haloperidol
- Identifier:
DOI
- 10.26300/x18h-nh36