Finding a more effective way to treat drug-resistant cancer cells is a huge task for scientists today. From our previous research, we are able to conclude that the mevalonate pathway is related to cancer cell proliferation and drug-resistant cell survival. We tested for a way to block the mevalonate pathway and its multiple feedback loops by pairing chemotherapy treatments with drugs like statins and sterols in the cancer cell line, OVCAR-8.
Le, Christy, and Caksa, Signe,
"Targeting the mevalonate pathway in drug resistance in ovarian cancer"
(2015).
Summer Research Symposium.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/mwjv-8491
Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …