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Targeting the mevalonate pathway in drug resistance in ovarian cancer


Finding a more effective way to treat drug-resistant cancer cells is a huge task for scientists today. From our previous research, we are able to conclude that the mevalonate pathway is related to cancer cell proliferation and drug-resistant cell survival. We tested for a way to block the mevalonate pathway and its multiple feedback loops by pairing chemotherapy treatments with drugs like statins and sterols in the cancer cell line, OVCAR-8.


Le, Christy, and Caksa, Signe, "Targeting the mevalonate pathway in drug resistance in ovarian cancer" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library.



  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …