Finding a more effective way to treat drug-resistant cancer cells is a huge task for scientists today. From our previous research, we are able to conclude that the mevalonate pathway is related to cancer cell proliferation and drug-resistant cell survival. We tested for a way to block the mevalonate pathway and its multiple feedback loops by pairing chemotherapy treatments with drugs like statins and sterols in the cancer cell line, OVCAR-8.
Le, Christy, and Caksa, Signe,
"Targeting the mevalonate pathway in drug resistance in ovarian cancer"
Summer Research Symposium.
Brown Digital Repository. Brown University Library.
Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …