Phenotypic profiling of persistent and non-persistent clinical isolates of Candida albicans

Description

Abstract:
Candida albicans, a species of yeast often found in the normal human gastrointestinal tract, is the most common cause of fungal bloodstream infections in US hospitals. Although C. albicans infections are often treated effectively with antifungal drugs, a subset of these infections evade drug treatment and persist by means other than developing antifungal drug resistance. This project investigates C. albicans clinical persistence by comparing virulence properties of persistent (drug-evading) and non-persistent clinical isolates, including their antifungal resistance, ability to grow, filament, invade and form biofilms. Comparisons were made between the first and last isolates collected from a single patient as well as between isolates that demonstrated rapid or delayed clearance following antifungal treatment. Delayed clearance isolates display higher levels of filamentation than rapid clearance isolates, suggesting that filamentation could play a role in C. albicans clinical persistence. However, each isolate has its own phenotypic profile and persistence can not be explained through single properties, suggesting it might be an emergent trait.\n\n

Citation

Navarrete, Karla, "Phenotypic profiling of persistent and non-persistent clinical isolates of Candida albicans" (2015). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/pmz7-vx59

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    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …

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