Title Information
Title
Phenotypic profiling of persistent and non-persistent clinical isolates of Candida albicans
Name
Name Part
Navarrete, Karla
Role
Role Term: Text
creator
Name: Personal
Name Part
Bennett, Richard
Role
Role Term: Text
advisor
affiliation
Brown University. Department of Molecular Microbiology and Immunology.
Name: Corporate
Name Part
Brown University. Undergraduate Teaching and Research Award
Role
Role Term: Text
research program
Type of Resource
still image
Genre (aat)
posters
Origin Information
Place
Place Term: Text
Providence
Publisher
Brown University
Date Created (keyDate="yes", encoding="w3cdtf")
2015-08-07
Physical Description
Extent (supplied="yes")
1 poster
digitalOrigin
reformatted digital
Language (usage="primary")
Language Term
eng
Abstract
Candida albicans, a species of yeast often found in the normal human gastrointestinal tract, is the most common cause of fungal bloodstream infections in US hospitals. Although C. albicans infections are often treated effectively with antifungal drugs, a subset of these infections evade drug treatment and persist by means other than developing antifungal drug resistance. This project investigates C. albicans clinical persistence by comparing virulence properties of persistent (drug-evading) and non-persistent clinical isolates, including their antifungal resistance, ability to grow, filament, invade and form biofilms. Comparisons were made between the first and last isolates collected from a single patient as well as between isolates that demonstrated rapid or delayed clearance following antifungal treatment. Delayed clearance isolates display higher levels of filamentation than rapid clearance isolates, suggesting that filamentation could play a role in C. albicans clinical persistence. However, each isolate has its own phenotypic profile and persistence can not be explained through single properties, suggesting it might be an emergent trait.\n\n
Subject (LCSH)
Topic
Candida albicans
Subject (LCSH)
Topic
Filamentous fungi
Subject (LCSH)
Topic
Antifungal agents
Identifier: DOI
10.26300/pmz7-vx59