- Title Information
- Title
- Biomedical Spectroscopy in Clinical Applications and Implications of Liquid Crystal Filter Technologies
- Name:
Personal
- Name Part
- McMurdy, John W.
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
(keyDate="yes", encoding="w3cdtf")
- 2008
- Physical Description
- Extent
- xviii, 179 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D.) -- Brown University (2008)
- Name:
Personal
- Name Part
- Crawford, Gregory
- Role
- Role Term:
Text
- director
- Name:
Personal
- Name Part
- Jay, Gregory
- Role
- Role Term:
Text
- director
- Name:
Personal
- Name Part
- Suner, Selim
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Zia, Rashid
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Broer, Dick
- Role
- Role Term:
Text
- reader
- Name:
Corporate
- Name Part
- Brown University. Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- This dissertation discusses two related clinical applications of visible regime diffuse reflectance spectroscopy as well as two new configurations of liquid crystal
microspectrometer suitable in these applications. Total hemoglobin concentration can be determined, and thus anemia diagnosed, using diffuse reflectance signals from the inner lining of the
eyelid, the palpebral conjunctiva. Alternative technologies for anemia detection are explored, a theoretical model for light diffusion through the conjunctiva is presented, and predictive models
are established relating spectral signatures to hemoglobin concentration. Two separate clinical trials were conducted showing accuracy of hemoglobin determination with respect to invasive
determination of 5% and 8% of mean hemoglobin concentration, respectively. Local hemoglobin concentration can also be determined in vivo at individual vessels using a single fiber which is
directly applicable in endoscopic and laparoscopic surgery. Clinical trials showed signal differentiation of different hemoglobin levels in laparoscopic cases when pressing the single fiber
against an individual vessel, and donor/recipient differentiation in fetal endoscopy cases of twin to twin transfusion syndrome. Liquid crystal technologies can be used to create integrated
chip-scale microspectrometers. In one configuration, analog tunable ferroelectric liquid crystals are applied to create a tunable filter spectrometer with resolution from 15-30 nm. In a second
configuration, stressed liquid crystal polymer composites are used to create large phase modulators, subsequently applied as single panel Fourier transform spectrometers. Proof of concept
studies show a 100 um stressed liquid crystal polymer in double pass mode is capable of 60 nm resolving power.
- Subject (Local)
- Topic
- Ferroelectric
- Subject (Local)
- Topic
- Spectroscopy
- Subject (Local)
- Topic
- Tissue Optics
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/999541")
- Topic
- Liquid crystals
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/923117")
- Topic
- Ferroelectricity
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/955053")
- Topic
- Hemoglobin
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/808617")
- Topic
- Anemia
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1129108")
- Topic
- Spectrum analysis
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20091218
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z0X928Q1
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations