- Title Information
- Title
- Stem-loop binding proteins (SLBP) regulates the expression of the HIV-1 restriction factor APOBEC3G
- Name:
Personal
- Name Part
- Cheruiyot, Collins
- Role
- Role Term:
Text (marcrelator)
- author
- Name:
Personal
- Name Part
- Li, Ming
- Role
- Role Term:
Text (marcauthority)
- advisor
- affiliation
- Brown University. Alpert Medical School
- Name:
Personal
- Name Part
- Gidas, Basilis
- Role
- Role Term:
Text (marcauthority)
- reader
- affiliation
- Brown University. Department of Applied Mathematics
- Type of Resource
- text
- Genre (aat)
- theses
- Origin Information
- Place
- Place Term:
Text
- Providence, RI
- Publisher
- Brown University
- Date Created
(keyDate="yes", encoding="w3cdtf")
- 2016-04-28
- Physical Description
- Extent
- 21 p.
- digitalOrigin
- reformatted digital
- Note
(displayLabel="Concentration")
- Applied Mathematics/Biology (ScB)
- Abstract
- Lymphocytes possess innate mechanisms for regulating the HIV-1 viral cycle. Using proteomics and functional analysis, we recently identified Stem-Loop Binding Protein (SLBP) as a histone related HIV-1 host factor that restricts integration and transcription of HIV-1. Our findings also demonstrated that SLBP depletion leads to a decrease in the HIV-1 restriction factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G) in lymphocytic cells at both the RNA and protein levels. In this study, we use various techniques to further investigate the molecular mechanism for the novel relationship between SLBP and APOBEC3G.
- Subject (LCSH)
- Topic
- HIV infections
- Subject (LCSH)
- Topic
- Apolipoprotein B
- Subject (Local)
- Topic
- SLPB
- Identifier:
DOI
- 10.7301/Z0F47MJR
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.