- Title Information
- Title
- The Development of Transdermal Power Delivery and Freely-Moving Behavioral Applications Of Titanium Enclosed, Wireless, Neural Recording Implantable Devices
- Name:
Personal
- Name Part
- Agha, Naubahar S
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
- 2016
- Physical Description
- Extent
- 38, 159 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D. -- Brown University (2016)
- Name:
Personal
- Name Part
- Nurmikko, Arto
- Role
- Role Term:
Text
- Director
- Name:
Personal
- Name Part
- Daniels, Jerry
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Mathiowitz, Edith
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Tripathi, Anubhav
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Yin, Ming
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- This study chronicles the development and application of a fully-implantable, battery powered, wireless, neural recording device to facilitate freely-moving behavioral studies, as well as therapeutic applications including epilepsy monitoring and brain-machine interfacing (BMI). This work expands on the implantable wireless neural interface, designed by Borton et al. [Journal of Neural Engineering, 2, 026010 (2013)], to transition it from experimental animal studies to human clinical use. The device life-span in an implanted setting was determined while also affirming its research potential with application specific studies. The device was successfully implanted and employed in behavioral experiments on multiple porcine as well as non-human primate animal models, for over 200 days each. The results showed that this active implantable device allows for a unique opportunity to study behavioral correlates of neural phenomena within unconstrained and freely-moving animal models of multiple species. Finally, a novel application of the Qi (pronounced "chee") wireless charging standard is incorporated as the transcutaneous energy transmission systems (TETS) to charge the battery within the active implantable device. This technology is implemented into the device utilizing a, slightly modified, off-the-shelf Qi compatible charger. Application specific designing and optimization of the wireless power transmission coil was performed. Our Qi inspired charging paradigm allows for our implantable device to be compatible with any Qi compatible wireless charger. Simulated implant conditions show that the internal heating of the device is compatible with the FDA regulated two degree Celsius rise from ambient conditions. In conclusion, the longevity of this device in an implanted setting has been validated, unique characteristics of the novel device were highlighted through specific research studies, and a consumer electronic wireless charging standard was integrated into the medical active implantable device territory.
- Subject
- Topic
- TETS
- Subject
- Topic
- transcutaneous energy transmission systems
- Subject
- Topic
- Wireless
- Subject
- Topic
- Implantable Device
- Subject
- Topic
- Neural Recording
- Subject
- Topic
- Neural Engineering
- Subject
- Topic
- Freely Moving Animal Models
- Subject
- Topic
- Swince
- Subject
- Topic
- Porcine
- Subject
- Topic
- Nonhuman Primate
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20160629
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z0930RKM
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations