Psychoneuroimmunology of Early Life Stress: Immune Response, Inflammation, and Illness in Healthy Adults

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Overview

Title
Psychoneuroimmunology of Early Life Stress: Immune Response, Inflammation, and Illness in Healthy Adults
Contributors
Gawuga, Cyrena (creator)
Zimmerman, Anita (Director)
Carpenter, Linda (Director)
Bui, Eric (Reader)
Morrow, Eric (Reader)
Bowen, Wayne (Reader)
Ayala, Alfred (Reader)
Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Doi
10.7301/Z0J38QXW
Copyright Date
2016
Abstract
A preponderance of evidence supports the assertion that low-grade inflammation resulting from exposure to ELS is associated with poor health outcomes in adulthood. To better understand how low-grade inflammation associated with ELS may contribute to increased morbidity in adulthood, studying a population that is free of medical and psychiatric illness is ideal in comparison to other methods. The high burden of illness borne by those with a history of ELS is well-recognized, and basic and clinical research has implicated inflammation as a factor. The studies presented were designed to investigate the hypothesis that subclinical symptoms of stress-related disorders can be identified in healthy adults prior to the development of clinically diagnosed illness, and that these symptoms are due to deleterious alterations in in both pro-inflammatory and anti-inflammatory immune signaling. Subclinical symptoms were associated with all ELS types. Although ELS types and pro-inflammatory immune mediators were not directly associated, the interaction between ELS and pro-inflammatory status predicted increased reports of subclinical symptoms. The anti-inflammatory cytokine adiponectin was not directly associated with ELS types or subclinical symptoms. However, in those adults who were overweight and had high adiponectin levels, the pro-inflammatory immune mediator was lower than CRP levels of overweight adults with low adiponectin levels, suggesting a protective effect. These results merit replication with a larger participant population to further examine observed findings.
Keywords
Early Life Stress
illness
Psychoneuroimmunology
Inflammation
Diseases
Notes
Thesis (Ph.D. -- Brown University (2016)
Extent
xiv, 170 p.

Citation

Gawuga, Cyrena, "Psychoneuroimmunology of Early Life Stress: Immune Response, Inflammation, and Illness in Healthy Adults" (2016). Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.7301/Z0J38QXW

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