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Contributor:: Olds, G. R. (creator); King, C. (creator); Hewlett, J. (creator); Olveda, R. (creator); Wu, G. (creator); Ouma, J. (creator); Peters, P. (creator); McGarvey, Stephen T. (creator); Odhiambo, O. (creator); Koech, D. (creator); Liu, C. Y. (creator); Aligui, G.. (creator); Gachihi, G. (creator); Kombe, Y. (creator); Parraga, I. (creator); Ramirez, B. (creator); Whalen, C. (creator); Horton, R. J. (creator); Reeve, P. (creator)
Genre:: articles
Subject:: Schistosomiasis; Philippines; Albendazole; Praziquantel; Public health; Health; China
DOI: https://doi.org/10.1086/314686

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Abstract:: A double‐blind placebo‐controlled study of the concurrent administration of albendazole and praziquantel was conducted in >1500 children with high prevalences of geohelminths and schistosomiasis. The study sites were in China and the Philippines, including 2 strains of Schistosoma japonicum, and 2 different regions of Kenya, 1 each with endemic Schistosoma mansoni or Schistosoma haematobium. Neither medication affected the cure rate of the other. There was no difference between the side effect rate from albendazole or the double placebo. Praziquantel‐treated children had more nausea, abdominal pain, and headache but these side effects were statistically more common in children with schistosomiasis, suggesting a strong influence of dying parasites. The subjects were followed for 6 months for changes in infection status, growth parameters, hemoglobin, and schistosomiasis morbidity. In all 4 sites, a significant 6‐month increase in serum hemoglobin was observed in children who received praziquantel, strongly supporting population‐based mass treatment.

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Olds, G. R., King, C., Hewlett, J., et al., "Double-blind placebo-controlled study of concurrent administration of Albendazole and Praziquantel in schoolchildren with Schistosomiasis and Geohelminths" Open Publications at Brown. Brown Digital Repository. Brown University Library. https://doi.org/10.1086/314686

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Open Publications at Brown

This collection contains public access and open access versions of scholarly publications authored and deposited by Brown University scholars, including faculty publications in compliance with the Brown Faculty Open Access Policy
Faculty and student publications include open access articles and …

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Double-blind placebo-controlled study of concurrent administration of Albendazole and Praziquantel in schoolchildren with Schistosomiasis and Geohelminths