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Modeling immunotherapy using alloreactive responses to treat leukemia

Description

Abstract:
Cancer is successful because it evades the immune system. Is it possible to induce a patient's immune system to overcome these inhibitory hurdles and attack the cancer? This approach has been found to induce strong immune responses by the patient which: Cause high fevers, eliminate donor cells (therefore no GVHD), generates anti-cancer responses in over half of patients. We are establishing a mouse model as a preclinical protocol to examine mechanisms and test new treatments. Question: If you harness this, will you actually get anti-leukemic responses? We already have had responses.

Citation

Hadid, Bana, and Rafelson, William, "Modeling immunotherapy using alloreactive responses to treat leukemia" (2016). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/xj6g-7209

Relations

Collection:

  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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