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Modeling immunotherapy using alloreactive responses to treat leukemia


Cancer is successful because it evades the immune system. Is it possible to induce a patient's immune system to overcome these inhibitory hurdles and attack the cancer? This approach has been found to induce strong immune responses by the patient which: Cause high fevers, eliminate donor cells (therefore no GVHD), generates anti-cancer responses in over half of patients. We are establishing a mouse model as a preclinical protocol to examine mechanisms and test new treatments. Question: If you harness this, will you actually get anti-leukemic responses? We already have had responses.


Hadid, Bana, and Rafelson, William, "Modeling immunotherapy using alloreactive responses to treat leukemia" (2016). Summer Research Symposium. Brown Digital Repository. Brown University Library.



  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …