<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" ID="bdr697273" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/mods/v3/mods-3-6.xsd">
   <mods:titleInfo>
      <mods:title>In vitro and histological analysis of polymer microsphere delivery</mods:title>
   </mods:titleInfo>
   <mods:name type="personal">
      <mods:namePart>Yakubov, Jonathan</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">creator</mods:roleTerm>
      </mods:role>
   </mods:name>
   <mods:name type="personal">
      <mods:namePart>Zhou, George</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">creator</mods:roleTerm>
      </mods:role>

   </mods:name>
   <mods:name type="personal">
      <mods:namePart>Léandre, Vérida</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">creator</mods:roleTerm>
      </mods:role>
      
   </mods:name>
   <mods:name type="personal">
      <mods:namePart>Baker, Christopher</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">creator</mods:roleTerm>
      </mods:role>
      
   </mods:name>
   
   <mods:name type="personal">
      <mods:namePart>Mathiowitz, Edith</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">advisor</mods:roleTerm>
      </mods:role>
      <mods:affiliation>Brown University. Department of Molecular Pharmacology, Physiology, and Biotechology</mods:affiliation>
   </mods:name>

   <mods:name type="corporate">
      <mods:namePart>Brown University. Undergraduate Teaching and Research Award</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">research program</mods:roleTerm>
      </mods:role>

   </mods:name>
   <mods:genre authority="aat">posters</mods:genre>
   <mods:originInfo>
      <mods:place>
         <mods:placeTerm type="text">Providence, RI</mods:placeTerm>
      </mods:place>
      <mods:publisher>Brown University</mods:publisher>
      <mods:dateCreated keyDate="yes" encoding="w3cdtf">2016</mods:dateCreated>
   </mods:originInfo>
   <mods:physicalDescription>
      <mods:extent>1 poster</mods:extent>
      <mods:digitalOrigin>reformatted digital</mods:digitalOrigin>
   </mods:physicalDescription>
   <mods:abstract>Cellular recruitment has diverse tissue engineering applications, ranging from wound healing to the treatment of metabolic disorders. Chemoattractants encapsulated in hydrogels, microspheres, scaffolds, and other systems have been studied as recruitment agents for a variety of these applications. Thus the goal of our project is to study how microspheres can be used to recruit progenitor cells. To achieve this, we histologically analyzed the presence of non-degradable polystyrene microspheres in rats delivered via either oral gavage or subcutaenous injection. These spheres serve as a model for bioresorbable polylactic acid microspheres. Next, we examined the effects that various solvents used during the histology process have on polymers, as their use can cause artefacts in histology slides. Lastly, we assayed cell response to dexamethsone, a drug involved in adipogenic differention. This work furthers our understanding of cell recruitment through microspheres and may aid in further development of recruitment based therapies</mods:abstract>
   <mods:subject authority="lcsh">
      <mods:topic>Microspheres</mods:topic>
   </mods:subject>
   <mods:subject authority="lcsh">
      <mods:topic>Cell proliferation</mods:topic>
   </mods:subject>
   <mods:subject authority="lcsh">
      <mods:topic>Polymers</mods:topic>
   </mods:subject>
   <mods:subject authority="lcsh">
      <mods:topic>Histology</mods:topic>
   </mods:subject>

<mods:identifier xmlns:xlink="http://www.w3.org/1999/xlink" type="doi">10.26300/e163-v417</mods:identifier><mods:typeOfResource xmlns:xlink="http://www.w3.org/1999/xlink">text</mods:typeOfResource></mods:mods>