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Year:: 2016
Contributor:: Rangwala, Aziz (creator); Murphy, Eileen L. (creator); Gregory, Steven T. (advisor); Jogl, Gerwald (advisor); Brown University. Undergraduate Teaching and Research Award (research program)
Genre:: posters
Subject:: Ribosomes; Streptomycin; Bacteria; Crystallography
Extent:: 1 poster
DOI: https://doi.org/10.26300/as5x-8332

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Abstract:: The ribosome is a molecular machine responsible for assembling proteins in cells using a process known as translation. Proteins are necessary for all life, so without properly functioning ribosomes, cells will die. Streptomycin is a common antibiotic that disrupts bacterial protein ribosomes by interfering with the ribosome's method of linking amino acids. With the rise of antibiotic-resistant strains of bacteria, it is essential to understand how these antibiotics halt bacterial growth. One such method to do so involves crystallizing both a normal strain of bacteria and a strain that is dependent on streptomycin for survival. Once we have determined the optimal crystallization conditions for these ribosome-antibiotic crystals, we can use X-ray diffraction to determine the three-dimensional structure of the interaction. Using this knowledge, we can then synthesize novel compounds that mimic this interaction for use in antibiotic-resistant strains of bacteria.

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Rangwala, Aziz, and Murphy, Eileen L., "Using x-ray crystallography to determine the effect of the antibiotic streptomycin on bacterial protein translation" (2016). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/as5x-8332

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Summer Research Symposium

Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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Using x-ray crystallography to determine the effect of the antibiotic streptomycin on bacterial protein translation