<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" ID="bdr697276" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/mods/v3/mods-3-6.xsd">
   <mods:titleInfo>
      <mods:title>Using x-ray crystallography to determine the effect of the antibiotic streptomycin on bacterial protein translation</mods:title>
   </mods:titleInfo>
   <mods:name type="personal">
      <mods:namePart>Rangwala, Aziz</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">creator</mods:roleTerm>
      </mods:role>
   </mods:name>
   <mods:name type="personal">
      <mods:namePart>Murphy, Eileen L.</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">creator</mods:roleTerm>
      </mods:role>
      <mods:affiliation>Brown University. Department of Molecular Biology, Cell Biology, and Biochemistry</mods:affiliation>
   </mods:name>
   <mods:name type="personal">
      <mods:namePart>Gregory, Steven T.</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">advisor</mods:roleTerm>
      </mods:role>
      <mods:affiliation>Brown University. Department of Molecular Biology, Cell Biology, and Biochemistry</mods:affiliation>
   </mods:name>
   <mods:name type="personal">
      <mods:namePart>Jogl, Gerwald</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">advisor</mods:roleTerm>
      </mods:role>
      <mods:affiliation>Brown University. Department of Molecular Biology, Cell Biology, and Biochemistry</mods:affiliation>
   </mods:name>

   <mods:name type="corporate">
      <mods:namePart>Brown University. Undergraduate Teaching and Research Award</mods:namePart>
      <mods:role>
         <mods:roleTerm type="text">research program</mods:roleTerm>
      </mods:role>

   </mods:name>
   <mods:genre authority="aat">posters</mods:genre>
   <mods:originInfo>
      <mods:place>
         <mods:placeTerm type="text">Providence, RI</mods:placeTerm>
      </mods:place>
      <mods:publisher>Brown University</mods:publisher>
      <mods:dateCreated keyDate="yes" encoding="w3cdtf">2016</mods:dateCreated>
   </mods:originInfo>
   <mods:physicalDescription>
      <mods:extent>1 poster</mods:extent>
      <mods:digitalOrigin>reformatted digital</mods:digitalOrigin>
   </mods:physicalDescription>
   <mods:abstract>The ribosome is a molecular machine responsible for assembling proteins in cells using a process known as translation. Proteins are necessary for all life, so without properly functioning ribosomes, cells will die. Streptomycin is a common antibiotic that disrupts bacterial protein ribosomes by interfering with the ribosome's method of linking amino acids. With the rise of antibiotic-resistant strains of bacteria, it is essential to understand how these antibiotics halt bacterial growth. One such method to do so involves crystallizing both a normal strain of bacteria and a strain that is dependent on streptomycin for survival. Once we have determined the optimal crystallization conditions for these ribosome-antibiotic crystals, we can use X-ray diffraction to determine the three-dimensional structure of the interaction. Using this knowledge, we can then synthesize novel compounds that mimic this interaction for use in antibiotic-resistant strains of bacteria.</mods:abstract>
   <mods:subject authority="lcsh">
      <mods:topic>Ribosomes</mods:topic>
   </mods:subject>
   <mods:subject authority="lcsh">
      <mods:topic>Streptomycin</mods:topic>
   </mods:subject>
   <mods:subject authority="lcsh">
      <mods:topic>Bacteria</mods:topic>
   </mods:subject>
   <mods:subject authority="lcsh">
      <mods:topic>Crystallography</mods:topic>
   </mods:subject>

<mods:identifier xmlns:xlink="http://www.w3.org/1999/xlink" type="doi">10.26300/as5x-8332</mods:identifier><mods:typeOfResource xmlns:xlink="http://www.w3.org/1999/xlink">text</mods:typeOfResource></mods:mods>