Introduction: Vitamin K is a fat-soluble vitamin, primarily stored in fat tissue and the liver. Vitamin K plays an important role in bone health but its role in osteoarthritis (OA) is under-researched. Currently there are no effective treatments to delay the progression of OA. We examined the prospective association of vitamin K with radiographic progression of knee osteoarthritis. We hypothesized that low vitamin would be associated with accelerated knee OA progression and high Vitamin K levels would be associated with protection. Methods: Osteoarthritis Initiative (OAI) is an ongoing cohort study evaluating risk factors and biomarkers for onset and progression of knee OA at 4 clinical centers including Memorial Hospital of Rhode Island/Brown University with 4796 participants. 1907 participants (2855 knees) with medial radiographic knee OA (Kellegren-Lawrence grad 2 and 3) and plausible dietary data at baseline were followed for 48 months for knee OA progression. Progression was defined by measured Joints Space Width (JSW) and semi-quantitative Joint Space Narrowing (JSN). Vitamin K was assessed using the Block Food Frequency Questionnaire measured at baseline. The residual method was used to adjust Vitamin K for total caloric intake. A generalized linear mixed model was used to examine the association of vitamin K and change in JSW and cox proportional hazard's model was used to examine JSN progression from baseline. Both modes adjusted for age, gender, race, and baseline KL grade. Results: We observed an inverse adjusted relationship between vitamin K intake and change in JSW (p=0.01). There also was an increase in JSN progression with decreasing levels of vitamin K (p<0.01)
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Citation
Horace, Reuben William, II,
"The association of Vitamin K deficiencies with accelerated knee osteoarthritis"
(2017).
Public Health Research Day.
Brown Digital Repository. Brown University Library.
https://doi.org/10.7301/Z0Z03645
Each spring Brown University's School of Public Health hosts Public Health Research Day. This event gathers together members of the public health community to present the latest research on how the public's health – both locally and abroad – is …
