Anxiety disorders pose a huge problem for today's youth. The present study aims at understanding the developmental trajectory of neural circuitry and anxiety development during adolescence. Our findings in mice suggest that anxiety may be reduced during early adolescence, when compared to pre-adolescence and late-adolescence. This decrease in anxiety may explain previously published work detailing a deficit in the ability to express a conditioned contextual fear memory during early adolescence. Here, we expand on our work by assessing the developmental trajectory of structures that project to the Basolateral Amygdala, a key structure in both the anxiety and fear circuits. Through this work we assess the link between circuit development and behavioral phenotypes.
Bravo, Marilyn,
"Development of the neural circuit of anxiety in adolescent mice"
(2017).
Summer Research Symposium.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/wrpf-tm13
Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
