Analysis of endogenous hormones in alcoholic smokers

Description

Abstract:
There is no approved treatment for dual alcohol/nicotine dependencies. A preliminary double-blind, placebo-controlled, randomized clinical study with 30 alcoholic smokers taking ү-Aminobutyric Acid (GABAB) receptor agonist, baclofen (80 mg/day), or placebo demonstrated the possible role of baclofen in treatment of alcoholic smokers. Blood samples were collected at Weeks 0-4-8-12 to analyze a series of hormone levels in 20 patients. The medication exposure was calculated as the area-under-the-curve (AUC) and an independent samples t-test was used to detect statistical difference. Patients taking baclofen reported lower levels of beta-endorphin compared to placebo. [t(18)=2.175, p=.043]. No differences were detected in other hormones tested. This study provides preliminary evidence suggesting a possible role of baclofen in the treatment of alcoholic smokers via hormone modulation.

Citation

Tran, Harrison, "Analysis of endogenous hormones in alcoholic smokers" (2017). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/wtn5-jg92

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