Analysis of endogenous hormones in alcoholic smokers

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Overview

Title
Analysis of endogenous hormones in alcoholic smokers
Contributors
Tran, Harrison (creator)
Haass-Koffler, Carolina (advisor)
Brown University. Karen T. Romer Undergraduate Teaching and Research Awards (research program)
Doi
10.26300/wtn5-jg92
Date Created
2017
Abstract
There is no approved treatment for dual alcohol/nicotine dependencies. A preliminary double-blind, placebo-controlled, randomized clinical study with 30 alcoholic smokers taking ү-Aminobutyric Acid (GABAB) receptor agonist, baclofen (80 mg/day), or placebo demonstrated the possible role of baclofen in treatment of alcoholic smokers. Blood samples were collected at Weeks 0-4-8-12 to analyze a series of hormone levels in 20 patients. The medication exposure was calculated as the area-under-the-curve (AUC) and an independent samples t-test was used to detect statistical difference. Patients taking baclofen reported lower levels of beta-endorphin compared to placebo. [t(18)=2.175, p=.043]. No differences were detected in other hormones tested. This study provides preliminary evidence suggesting a possible role of baclofen in the treatment of alcoholic smokers via hormone modulation.
Keywords
Baclofen
beta-Endorphin
Oxytocin
Extent
1 poster

Citation

Tran, Harrison, "Analysis of endogenous hormones in alcoholic smokers" (2017). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/wtn5-jg92

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    Each year, Brown showcases the research of nearly 200 undergraduates at our Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships. Presenters include ...

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