High loading poly (lactic acid) nanoparticles as a vehicle for sustained insulin release

Calvao, Dominick

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Overview

Year:: 2017
Contributor:: Calvao, Dominick (creator); Mathiowitz, Edith (Advisor); Hoffman-Kim, Diane (Reader); Shukla, Anita (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Nanoparticles; Drug delivery systems; Polymeric drug delivery systems; Oral Drug Delivery; Polymeric nanoparticles
Extent:: viii, 30 p.
DOI: https://doi.org/10.7301/Z07P8WV4

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Description

Abstract:: Diabetics will typically take an insulin regimen with fast acting bolus insulin and long acting basal insulin. The most common methods of delivering this insulin is by using syringes and insulin pumps. However, these methods have significant drawbacks and low user compliance. Effective oral insulin delivery has long been sought after as it is believed that user compliance will increase if an insulin pill were to become available. Using phase inversion nanoencapsulation insulin has been successfully encapsulated in poly (lactic acid). Sustained insulin release was achieved for a period of up to one week. The method of insulin preparation, called micronization, was of particular importance for controlling the release kinetics of the insulin. This technology has potential to replace the basal insulin injections diabetics currently must self-administer.
Notes:: Thesis (Sc. M.)--Brown University, 2017

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Rights: In Copyright
Restrictions on Use: Collection is open for research.

Citation

Calvao, Dominick, "High loading poly (lactic acid) nanoparticles as a vehicle for sustained insulin release" (2017). Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.7301/Z07P8WV4

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Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations

Theses and Dissertations for the Molecular Pharmacology, Physiology, and Biotechnology department.
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