- Title Information
- Title
- Injectable Rosette Nanotube Nanomatrix for Localization of Bioactive Protein for Growth Plate Repair
- Type of Resource
- text
- Name:
Personal
- Name Part
- Lam, Peter
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Chen, Yupeng
- Role
- Role Term:
Text
- Advisor
- Name:
Personal
- Name Part
- Darling, Eric
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Schell, Jacquelyn
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Biology and Medicine: Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Origin Information
- Copyright Date
- 2017
- Physical Description
- Extent
- v, 33 p.
- digitalOrigin
- born digital
- Note:
thesis
- Thesis (Sc. M.)--Brown University, 2017
- Genre (aat)
- theses
- Abstract
- Growth plate fracture is a serious injury that affects children and adolescents. These types of fractures can occur from physical sports, a fall or from overuse. The most common growth plate fractures occur in the phalanges or in the bones in the lower area of the leg such as the tibia and fibula. These fractures can lead to uneven bone growth and bone deformity if left untreated due to bony bridge formation in the cartilage area. The current treatments for growth plate fractures involve immobilization or surgery, depending on the severity of the injury. Surgery involves the removal of the bony bridge and implantation of autologous fat tissue or screws to discourage further bony bridge formation. The disadvantage of surgery is that it is very invasive and is often unsuccessful. Therefore, there is a need for a better therapy to treat growth plate fractures.
This study explores a novel therapy using a nanomatrix made up of rosette nanotubes and matrilin-3 to treat growth plate fractures. The aim of this study is to characterize the nanomatrix as well as assess its efficacy in vivo. The results indicate the delivery of matrilin-3 in a matrix with rosette nanotubes is able to sustain the protein inside the injury site longer to prolong its therapeutic effect. Moreover, the results assessing the efficacy of the nanomatrix indicate improved healing of the growth plate fracture by minimizing the degree of bone deformity.
- Subject
- Topic
- Growth plate fracture
- Subject
- Topic
- Rosette Nanotubes
- Subject
- Topic
- Matrilin-3
- Subject
- Topic
- Nanomatrix
- Language
- Language Term (ISO639-2B)
- English
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20170616
- Identifier:
DOI
- 10.7301/Z0PC30VD
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.