- Title Information
- Title
- Acetylcholine Supports Olfactory Perceptual Learning through Adult Neurogenesis
- Name:
Personal
- Name Part
- Nitenson, Arielle Nicole Price Schilit
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Bath, Kevin
- Role
- Role Term:
Text
- Advisor
- Name:
Personal
- Name Part
- Fallon, Justin
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Moore, Christopher
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Mandairon, Nathalie
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Department of Neuroscience
- Role
- Role Term:
Text
- sponsor
- Origin Information
- Copyright Date
- 2017
- Physical Description
- Extent
- 23, 198 p.
- digitalOrigin
- born digital
- Note:
thesis
- Thesis (Ph. D.)--Brown University, 2017
- Genre (aat)
- theses
- Abstract
- Learning to perceptually discriminate chemical signals in our environment (olfactory perceptual learning) is critical for survival. Multiple mechanisms have been implicated in olfactory perceptual learning, including modulation of neurogenesis and manipulation of cholinergic activity. However, the relative contribution of these mechanisms to olfactory perceptual learning has remained unclear. Using a combination of pharmacological and optogenetic approaches, we found that cholinergic activity is both necessary and sufficient to support olfactory perceptual learning, and that this process is dependent upon the presence of newly born cells in the olfactory bulb. We also determined that olfactory perceptual learning leaves a long-term odorant memory. This study is the first to directly link cholinergic activity and neurogenesis to support olfactory perceptual learning.
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00795604")
- Topic
- Acetylcholine
- Subject
- Topic
- Adult Neurogenesis
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01057653")
- Topic
- Perceptual learning
- Subject
- Topic
- Olfaction
- Language
- Language Term (ISO639-2B)
- English
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20170616
- Identifier:
DOI
- 10.7301/Z0610XSR
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations