<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-4.xsd"><mods:titleInfo><mods:title>Acetylcholine Supports Olfactory Perceptual Learning through Adult Neurogenesis</mods:title></mods:titleInfo><mods:name type="personal"><mods:namePart>Nitenson, Arielle Nicole Price Schilit</mods:namePart><mods:role><mods:roleTerm type="text">creator</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Bath, Kevin</mods:namePart><mods:role><mods:roleTerm type="text">Advisor</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Fallon, Justin</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Moore, Christopher</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Mandairon, Nathalie</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="corporate"><mods:namePart>Brown University. Department of Neuroscience</mods:namePart><mods:role><mods:roleTerm type="text">sponsor</mods:roleTerm></mods:role></mods:name><mods:originInfo><mods:copyrightDate>2017</mods:copyrightDate></mods:originInfo><mods:physicalDescription><mods:extent>23, 198 p.</mods:extent><mods:digitalOrigin>born digital</mods:digitalOrigin></mods:physicalDescription><mods:note type="thesis">Thesis (Ph. D.)--Brown University, 2017</mods:note><mods:genre authority="aat">theses</mods:genre><mods:abstract>Learning to perceptually discriminate chemical signals in our environment (olfactory perceptual learning) is critical for survival. Multiple mechanisms have been implicated in olfactory perceptual learning, including modulation of neurogenesis and manipulation of cholinergic activity. However, the relative contribution of these mechanisms to olfactory perceptual learning has remained unclear. Using a combination of pharmacological and optogenetic approaches, we found that cholinergic activity is both necessary and sufficient to support olfactory perceptual learning, and that this process is dependent upon the presence of newly born cells in the olfactory bulb. We also determined that olfactory perceptual learning leaves a long-term odorant memory. This study is the first to directly link cholinergic activity and neurogenesis to support olfactory perceptual learning.</mods:abstract><mods:subject authority="fast" authorityURI="http://id.worldcat.org/fast" valueURI="http://id.worldcat.org/fast/00795604"><mods:topic>Acetylcholine</mods:topic></mods:subject><mods:subject><mods:topic>Adult Neurogenesis</mods:topic></mods:subject><mods:subject authority="fast" authorityURI="http://id.worldcat.org/fast" valueURI="http://id.worldcat.org/fast/01057653"><mods:topic>Perceptual learning</mods:topic></mods:subject><mods:subject><mods:topic>Olfaction</mods:topic></mods:subject><mods:language><mods:languageTerm authority="iso639-2b">English</mods:languageTerm></mods:language><mods:recordInfo><mods:recordContentSource authority="marcorg">RPB</mods:recordContentSource><mods:recordCreationDate encoding="iso8601">20170616</mods:recordCreationDate></mods:recordInfo><mods:identifier type="doi">10.7301/Z0610XSR</mods:identifier><mods:accessCondition type="rights statement" xlink:href="http://rightsstatements.org/vocab/InC/1.0/">In Copyright</mods:accessCondition><mods:accessCondition type="restriction on access">Collection is open for research.</mods:accessCondition><mods:typeOfResource authority="primo">dissertations</mods:typeOfResource></mods:mods>