The Aging Heart: Mechanisms of Arrhythmogenesis and Sudden Cardiac DeathMurphy, Kevin RonaldcreatorKoren, GideonAdvisorSedivy, JohnReaderRand, DavidReaderTatar, MarcReaderSheu, Shey-ShingReaderBrown University. Department of Molecular Biology, Cell Biology and Biochemistrysponsor201818, 165 p.born digitalThesis (Ph. D.)--Brown University, 2018thesesThe incidence of sudden cardiac death increases 5 to 40–fold in humans over 65 years as compared to younger individuals. The mechanisms underlying this phenomena at the cellular and organ levels remain elusive. Thus, it is critical to discover novel pathways that will lead to triggers that initiate ventricular arrhythmias and the substrate that will maintain these arrhythmias and will thereby lead to sudden cardiac death (SCD). To that end, it is essential to use a large animal model that will enable us to investigate the mechanisms of SCD to better understand and eventually prevent SCD in humans.AgingSudden Cardiac DeathEnglishRPB2018061510.26300/5dga-1e67In CopyrightCollection is open for research.dissertations