Role of Mechanophenotype in Cell-Substrate Interactions

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Overview

Title
Role of Mechanophenotype in Cell-Substrate Interactions
Contributors
Shah, Manisha (creator)
Darling, Eric (Advisor)
Morgan, Jeffrey (Reader)
Wong, Ian (Reader)
Coulombe, Kareen (Reader)
Slater, John (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Copyright Date
2018
Abstract
Cellular mechanophenotype is defined as the elastic and viscoelastic properties of a cell, and is commonly characterized by atomic force microscopy (AFM). Assessment of a cell’s mechanophenotype in the larger context of its microenvironment can add to increased understanding of biological phenomena such a cellular organization, proliferation, shape, motility, and differentiation. Here, we aim to (1) characterize the mechanical properties and differentiation potential of cells present in human lipoaspirate, (2) examine the influence of inherent mechanophenotype on cell-cell-substrate organization, and (3) assess incorporation of compliant microparticles into cancer vs. normal spheroids.
Keywords
Atomic force microscopy
adipose derived stem cells
mechanophenotype
microparticles
Notes
Thesis (Ph. D.)--Brown University, 2018
Extent
xv, 128 p.

Citation

Shah, Manisha, "Role of Mechanophenotype in Cell-Substrate Interactions" (2018). Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://repository.library.brown.edu/studio/item/bdr:792653/

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