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Supplementary file from manuscript "A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures"

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Overview

Year:
2016
Contributor:
Rodd, April L. (Creator)
Messier, Norma J. (Creator)
Vaslet, Charles A. (Creator)
Kane, Agnes B. (Creator)
Subject:
animal alternatives
cytochrome P450 1A
Cyp1a
fish
hepatocytes
morphology
polycyclic aromatic hydrocarbons
PAHs
DOI
https://doi.org/10.26300/cp9j-mt02

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Description

Abstract:
Supplementary files for manuscript "A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposuresPMID: 28282620 and PMCID: PMC5436724. Version of Record is Published in Edited Form as: Aquatix Toxicology. 2017 May;186:134-144. doi:10.1016/j.aquatox.2017.02.018.This study characterizes a novel fish liver microtissue model, produced with the cell line PLHC-1, as an in vitro aquatic toxicity testing platform. These 3D microtissues remain viable and stable throughout the 8-day testing period and relative to 2D monolayers, show increased basal expression of the xenobiotic metabolizing enzyme cytochrome P450 1A (Cyp1a).
Notes:
This work was supported by NIEHS Superfund Research Program Grant P42 ES013660 and the generous support of Donna McGraw Weiss and Jason Weiss. A.L.R. is funded by NIEHS Training Grant T32 ES007272 and the Institute at Brown for Environment and Society (IBES).

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This work is licensed under a Creative Commons Attribution 4.0 International License

Citation

Rodd, April L., Messier, Norma J., Vaslet, Charles A., et al., "Supplementary file from manuscript 'A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures'" (2016). Brown Superfund Data Products, Brown Superfund Project 2: Adverse Human Health Impacts of Nanomaterials Digital Archive, Brown University Open Data Collection. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/cp9j-mt02

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