<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-4.xsd">
<mods:titleInfo>
<mods:title>Author manuscript: "A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures"</mods:title>
</mods:titleInfo>
<mods:abstract>This is a post-print manuscript of the article allowed by the publisher to be deposited in the Brown Digital Repository. This study characterizes a novel fish liver microtissue model, produced with the cell line PLHC-1, as an in vitro aquatic toxicity testing platform. These 3D microtissues remain viable and stable throughout the 8-day testing period and relative to 2D monolayers, show increased basal expression of the xenobiotic metabolizing enzyme cytochrome P450 1A (Cyp1a). This study demonstrates the capabilities of this PLHC-1 microtissue model for sensitive assessment of liver toxicants over time and following single and repeated exposures.</mods:abstract>
<mods:name>
<mods:namePart>Rodd, April L.</mods:namePart>
<mods:role>
<mods:roleTerm authority="marcrelator" authorityURI="http://id.loc.gov/vocabulary/relators" valueURI="http://id.loc.gov/vocabulary/relators/aut">Author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name>
<mods:namePart>Messier, Norma J.</mods:namePart>
<mods:role>
<mods:roleTerm authority="marcrelator" authorityURI="http://id.loc.gov/vocabulary/relators" valueURI="http://id.loc.gov/vocabulary/relators/aut">Author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name>
<mods:namePart>Vaslet, Charles A.</mods:namePart>
<mods:role>
<mods:roleTerm authority="marcrelator" authorityURI="http://id.loc.gov/vocabulary/relators" valueURI="http://id.loc.gov/vocabulary/relators/aut">Author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name>
<mods:namePart>Kane, Agnes B.</mods:namePart>
<mods:role>
<mods:roleTerm authority="marcrelator" authorityURI="http://id.loc.gov/vocabulary/relators" valueURI="http://id.loc.gov/vocabulary/relators/aut">Author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:originInfo>
<mods:dateCreated>2017</mods:dateCreated>
</mods:originInfo>
<mods:subject authority="local">
<mods:topic>animal alternatives</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>cytochrome P450 1A</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>Cyp1a</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>fish</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>hepatocytes</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>morphology</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>polycyclic aromatic hydrocarbons</mods:topic>
</mods:subject>
<mods:subject authority="local">
<mods:topic>PAHs</mods:topic>
</mods:subject>
<mods:typeOfResource>text</mods:typeOfResource>
<mods:genre>research article</mods:genre>
<mods:note type="funding">This work was supported by NIEHS Superfund Research Program Grant P42 ES013660 and the generous support of Donna McGraw Weiss and Jason Weiss. A.L.R. is funded by NIEHS Training
Grant T32 ES007272 and the Institute at Brown for Environment and Society (IBES).</mods:note>
</mods:mods>