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Impact of the Host Metabolism on Bacterial Antibiotic Responses


Antibiotic resistance is bacteria’s ability to resist treatment with an antibiotic. Every year, more people become infected with increasingly resistant strains of bacteria, which in some cases can have fatal results. With this project we hope to expand our knowledge and understanding of the relationship between the host microbiome and the antibiotic responses of Methicillin- resistant Staphylococcus aureus (MRSA). We hypothesize that the state of a host’s metabolism can affect the metabolism of the bacteria within it, and in turn contribute to antibiotic tolerance. We aim to identify the genes that are involved in antibiotic tolerance and glucose metabolism in an in vitro model. We also seek to determine the impacts of induced hyperglycemia on the tolerance of S. aureus in an in-vivo mouse model. We expect to find that the host metabolic state has an effect on bacterial metabolism which could lead to the inactivation of protective glucose pathways that usually allow for tolerance when challenged with antibiotics. We also expect to find that the in vivo hypoglycemic model will show an increase in infectivity of S. aureus, as well as a decrease in pathogen clearance. If these goals are fulfilled, they will contribute to the way we approach the use of antibiotics and help in the fight against antibiotic resistance.


Ortiz, Melanie, Wurster, Jenna, and Belenky, Peter, "Impact of the Host Metabolism on Bacterial Antibiotic Responses" (2018). The Leadership Alliance Digital Library, Summer Research Symposium. Brown Digital Repository. Brown University Library.



  • The Leadership Alliance Digital Library

    A collection of research presentations and posters created by students participating in the Leadership Alliance's Summer Research - Early Identification Program.

    When using this resource, please cite the digital object identifier (DOI) for the specific resource as well as the …

  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …