Title Information
Title
Impacts of genotoxic agents on rates of ribosomal mutations in the 30S ribosomal rspE gene.
Abstract
The RspE gene is responsible for encoding a portion of the 30S ribosomal subunit in B. subtilis. Single nucleotide mutations in the RspE gene provide protection from the effects of the ribosome targeting antibiotic spectinomycin. The goal of the project is to study the impacts of genotoxic agents on the mutations in the RspE gene. We will define whether specific treatments result in different mutation rates or a preference for specific nucleotide changes. Sequencing a library of these mutants using the Illumina next generation sequencing platform will allow to characterize the mutations and observe how various genotoxic agents impact mutation types and rates.
Name: Personal
Name Part
Lee, Stella
Role
Role Term: Text
creator
Name: Personal
Name Part
Peter Belenky
Role
Role Term: Text
advisor
affiliation
Brown University. MMI
Name: Corporate
Name Part
Brown University. Karen T. Romer Undergraduate Teaching and Research Awards
Role
Role Term: Text
research program
Subject (fast) (authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00898704")
Topic
Drug resistance in microorganisms
Language
Language Term: Text (ISO639-2B)
English
Type of Resource
still image
Genre (aat)
posters
Origin Information
Place
Place Term: Code (MARC Country Code)
riu
Place
Place Term: Text
Providence, RI
Publisher
Brown University
Date Created (keyDate="yes", encoding="w3cdtf")
2018
Physical Description
Extent
1 poster
digitalOrigin
born digital
Identifier: DOI
10.26300/fxsn-p449