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Year:: 2018
Contributor:: Rodríguez-Villafañe, Andrea (creator); Jonathan Kurtis (advisor); Leadership Alliance-Summer Research Early Identification Program (SR-EIP) (research program)
Genre:: posters
Subject:: Plasmodium falciparum; Malaria vaccine; Malaria
Extent:: 1 poster
DOI: https://doi.org/10.26300/1qdw-vy61

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Abstract:: P. falciparum is the most dangerous species of human malarial parasite, responsible for the majority of deaths attributed to malaria. Murine models have been extensively used in literature to study host immune response against pathogens. In this project, we explored if mice vaccinated with P. falciparum infected human RBCs produce functional antibodies, which can inhibit the growth and multiplication of malaria parasites in culture. P. falciparum infected RBCs were enriched (up to 90%) from a culture with 5% parasitemia using immuno-magnetic enrichment methods and used for the injection of mice at 2-week intervals. Two weeks after the final immunization, P. falciparum specific antibodies were measured in the serum to perform parasite growth inhibition assay (GIA). We did not find significantly high antibody titer to perform GIA since only two injections were done within the permitted time.

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Citation

Rodríguez-Villafañe, Andrea, "Evaluation of the anti-parasitic effect of Plasmodium falciparum specific murine antibodies in in vitro assays" (2018). The Leadership Alliance Digital Library, Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/1qdw-vy61

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The Leadership Alliance Digital Library

A collection of research presentations and posters created by students participating in the Leadership Alliance's Summer Research - Early Identification Program.
When using this resource, please cite the digital object identifier (DOI) for the specific resource as well as the …

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Summer Research Symposium

Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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Evaluation of the anti-parasitic effect of Plasmodium falciparum specific murine antibodies in in vitro assays