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Year:: 2018
Contributor:: Beltoja, Marjo (Creator); Berson, David (advisor); Hai, Chi-Ming (reader); Brown University (sponsor)
Genre:: theses
Subject:: Retina; ipRGCs; contrast; amacrine; intensity
Extent:: 61 p.
DOI: https://doi.org/10.26300/xarg-hw87

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Description

Abstract:: We propose that selected ipRGCs form electrical gap junctions with a special type of wide-eld amacrine cell known as the Type 2 Polyaxonal Amacrine Cell (PAC2). These PACs, in turn, distribute the intensity information across the retina and modulate the contrast-encoding pathway. We tested this hypothesis by reconstructing a PAC2 and its postsynaptic partners in a serial electron microscopy dataset. The axons of PAC2s were scanned for membrane swelling or the presence of vesicles in order to reconstruct the BCs, RGCs and ACs receiving input from the PAC2s.
Notes:: Senior thesis (AB)--Brown University, 2018; Concentration: Biophysics

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Rights: In Copyright
Restrictions on Use: Collection is open for research.

Citation

Beltoja, Marjo, "The Role of Type 2 Polyaxonal Amacrine Cells (PAC2) in mediating light adaptation" (2018). Biomedical Engineering Theses and Dissertations, Biology and Medicine Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/xarg-hw87

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Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.
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Biology and Medicine Theses and Dissertations

Theses and Dissertations for the Biology and Medicine department.
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The Role of Type 2 Polyaxonal Amacrine Cells (PAC2) in mediating light adaptation