Behavioral Phenotyping in Mouse: Accelerating Therapeutic Development for Neurodegenerative Diseases

Page, John Sherman

Full Metadata

Overview

Year:: 2019
Contributor:: Page, John Sherman (creator); Fallon, Justin (Advisor); Reenan, Robert (Reader); Marshall, John (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Amyotrophic lateral sclerosis; Alzheimer's disease; Mouse behavior; Nervous system--Degeneration
Extent:: 6, 44 p.
DOI: https://doi.org/10.26300/x720-xs14

Files

Description

Abstract:: Neurodegenerative disease is one of the greatest yet poorest understood medical challenges facing humanity today. A fundamental hurdle that continues to frustrate therapeutic development is a lack of a clear understanding of disease mechanisms. The use of animal models represents a tremendous opportunity to learn about disease mutations and subsequent pathophysiology. Behavioral testing enables the study of various facets of disease, and can give insight into potential therapeutic avenues. This thesis describes muscular and metabolic phenotyping of a knock-in mouse model of ALS to provide a benchmark to assess efficacy in future suppressor testing. This thesis also reports on increased hippocampal-dependent memory as a result of increased neurogenesis by modulating a novel signaling pathway in the brain, paving the way for potential therapeutic development for diseases of impaired memory and/or hippocampal neurogenesis.
Notes:: Thesis (Sc. M.)--Brown University, 2019

Content

Access Conditions

Rights: In Copyright

Citation

Page, John Sherman, "Behavioral Phenotyping in Mouse: Accelerating Therapeutic Development for Neurodegenerative Diseases" (2019). Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/x720-xs14

Relations

Collection:

Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations

Theses and Dissertations for the Molecular Pharmacology, Physiology, and Biotechnology department.
...