- Title Information
- Title
- Antagonistic effect of aspartate-β-hydroxylase on chemotherapeutics in cholangiocarcinoma
- Type of Resource
- text
- Name:
Personal
- Name Part
- Cao, Kevin
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Wands, Jack
- Role
- Role Term:
Text
- Advisor
- Name:
Personal
- Name Part
- Huang, Chiung-Kuei
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Li, Ji Su
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology
- Role
- Role Term:
Text
- sponsor
- Origin Information
- Copyright Date
- 2019
- Physical Description
- Extent
- , 37 p.
- digitalOrigin
- born digital
- Note:
thesis
- Thesis (Sc. M.)--Brown University, 2019
- Genre (aat)
- theses
- Abstract
- Bile duct cancer, known as cholangiocarcinoma (CCA), is a rare but highly aggressive cancer with a 3% incident in all gastrointestinal cancers. The only known curative treatment for CCA is surgical resection at an early stage, however, CCA is usually asymptomatic until advanced local or metastatic stages where surgical resection may not be considered curative or possible therapy. Aspartate-β-hydroxylase (ASPH) is a type 2 transmembrane protein that is frequently found to be upregulated in a number of cancers including CCA. The expression of ASPH has been associated with a poorer prognosis and a worse response to chemotherapy. Here, we examine the role of ASPH in chemotherapy and how it influences the DNA damage response.
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00886581")
- Topic
- DNA damage
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00831700")
- Topic
- Bile ducts--Cancer
- Subject
- Topic
- ASPH
- Language
- Language Term (ISO639-2B)
- English
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20190603
- Identifier:
DOI
- 10.26300/e9nv-a670
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.