Development of Laminin Matrix Stripes on Polyacrilamide to Geometrically Confine Neurons in a One-Dimensional Space

Klotz, Daniel John

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Year:: 2018
Contributor:: Klotz, Daniel John (creator); Franck, Christian (Advisor); Schell, Jacquelyn (Reader); Miller, Kenneth (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: traumatic brain injury; Brain damage; Brain--Concussion; Pediatric Head Trauma; Mild Traumatic Brain Injury
Extent:: viii, 28 p.
DOI: https://doi.org/10.26300/tpta-k049

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Abstract:: Traumatic brain injury (TBI) is one of the most difficult injuries to quantify. Many people with a TBI are not even aware that they have one, and a substantial number go unreported by clinics, sports teams, and sources that don’t wish to disclose information. Despite this, traumatic brain injury accounts for 30% of all injury related deaths. Adding up instances that occurred in 2013, 2.5 million ED visits, 282,000 TBI-related hospitalizations, and 56,000 TBI-related deaths show the staggering impact that TBI has yearly on the United States; and this number is only rising. From 2001 to 2010, hospital emergency departments saw an increase of 70% in traumatic brain injury visits. Hospitalizations and deaths both increased about 10% each. [36] Given unreported incidences and population growth the real numbers are likely much higher. [34, 35, 38] Of all TBIs, about 75% are believed to be in the subsection of MTBIs or ’mild’ traumatic brain injury. Concussions are included in the subsection of MTBI. MTBIs account for close to 3.8 million incidences annually, which may account for billions of dollars in lost money and productivity in the United States every year, according to the CDC. [8, 32, 33] Although MTBIs are classified as a major public health concern and have heavy links to Parkinson’s and Alzheimer’s diseases, not much headway has been made regarding long-term treatment of MTBIs. The complexity of the brain and the pathways involved make it difficult to reliably quantify or qualify different mechanisms that take place during a TBI. Further, most singular in-vitro research in the MTBI sphere mainly contain neurons that develop outgrowths that stretch in random directions and do little to mimic highly oriented and organized brain conditions. [12, 30, 31]
Notes:: Thesis (Sc. M.)--Brown University, 2018

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Citation

Klotz, Daniel John, "Development of Laminin Matrix Stripes on Polyacrilamide to Geometrically Confine Neurons in a One-Dimensional Space" (2018). Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/tpta-k049

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Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations

Theses and Dissertations for the Molecular Pharmacology, Physiology, and Biotechnology department.
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