This project consists of several applications of fluorescent probe chemistry to analyze sulfane sulfur activity in the field of chemical biology. Recently, it's been discovered that cells utilize sulfane sulfurs in a variety of physiological functions. The detection and manipulation of sulfur compounds in cell environments is one of the most useful ways to study the purpose and mechanisms of these functions. SSP4, developed by the Xian Lab, serves a variety of purposes in this project and its utility is expanded in studying post-transcriptional protein modification, novel sulfane sulfur donors, fluorescence live cell imaging, and more.
Zdon, Alan,
"Applications of SSP4 for the Study of Sulfur-Based Chemical Biology"
(2022).
Summer Research Symposium.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/yjh4-7d95
Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
