- Title Information
- Title
- Supplementary material from "Differential toxicity of water versus gavage exposure to trichloroethylene in rats"
- Abstract
- Trichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gavage exposures (1000 mg/kg/day) and through drinking water (0.6% TCE) for 14 weeks. The gavage route resulted in reversible reduction of epididymis weight, and reduced body weight that persisted for up to 12-weeks after cessation of exposure. Physiologically-based pharmacokinetic modeling predicted that the gavage route results in higher C max and AUC exposure of TCE compared to drinking water exposure, explaining the observed differences in toxicity between dosing regimens.
- Name:
Personal
- Name Part
- Stermer, Angela R.
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Text
- creator
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Personal
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- Klein, David
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- creator
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- Wilson, Shelby K.
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- creator
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Personal
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- Dalaijamts, Chimeddulam
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- creator
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Personal
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- Yue Bai, Cathy
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- creator
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Personal
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- Hall, Susan J.
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- creator
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Personal
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- Madnick, Samantha
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Personal
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- Bianchi, Enrica
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- creator
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Personal
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- Chiu, Weihsueh A.
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Personal
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- Boekelheide, Kim
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- Role Term:
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- creator
- Origin Information
- Date Created
(keyDate="yes", encoding="w3cdtf")
- 2019
- Genre
- supplementary material
- Type of Resource
- multimedia
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01156552")
- Topic
- Trichloroethylene
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01153336")
- Topic
- Toxicity testing
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01090300")
- Topic
- Rats
- Language
- Language Term:
Text (ISO639-2B)
- English
- Note:
funding
- This research is supported by the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42ES013660
- Access Condition:
use and reproduction
(href="https://creativecommons.org/licenses/by/4.0/legalcode")
- Attribution 4.0 International (CC BY 4.0)
- Access Condition:
logo
(href="https://licensebuttons.net/l/by/4.0/88x31.png")