Inhibition of Voltage-Gated CaV2.2 Calcium Channels in Peripheral Nociceptor Nerve Endings Prevents Neurogenic Hyperalgesia in MiceChronic pain is a condition that lacks effective treatment. Nerve injury and inflammation can lead to chronic unrelenting pain in a significant number of individuals. New, non-additive, non-opioid therapies are needed. Voltage gated CaV2.2 calcium channels are essential for mediating noxious signals that are perceived as pain, and they also contribute to pathological pain. Inhibitors of CaV2.2 calcium channels are effective analgesics but their use in the clinic has so far been limited to intrathecal application. Here we assess the function of CaV2.2 channels at nociceptor nerve endings in skin. We ask if peripheral CaV2.2 channels have a role in neurogenic hyperalgesia.Li, DanielAuthorSoto Lopez, E JavierAuthorDuBreuil, DanielAuthorLipscombe, DianeAuthorBrown University. Alpert Medical School. Scholarly Concentration Program. Non-Scholarly Concentratorresearch programChronic painCalcium channelsTransgenic miceHyperalgesiaNociceptive painNociceptorsNerves, PeripheralEnglish2019Non-Scholarly ConcentratorAll rights reservedtext