<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-8.xsd">
  <mods:titleInfo>
    <mods:title>MATLAB script to analyze efficacy and safety data of plasmonic retinal prosthesis</mods:title>
  </mods:titleInfo>
<mods:typeOfResource authority="primo">research_datasets</mods:typeOfResource>
  <mods:abstract>Retinal prostheses seek to restore vision in degenerative diseases such as age-related macular degeneration and retinitis pigmentosa. Current methods, including implantable electrodes and optogenetics, are limited by invasiveness and/or spatial resolution, and some nanoparticle-based approaches require intense visible light that could disrupt residual vision. Plasmonic gold nanorods (AuNRs) tuned for near-infrared (NIR) absorption enable photothermal neuromodulation while avoiding visible-light interference, but their use with patterned stimulation for precise activation remains underexplored. Here, we present an intravitreal, anti-Thy1–AuNR strategy that enables wide retinal coverage and primarily engages bipolar cells, a target typically accessed via subretinal injection. Patterned NIR stimulation with a 20 μm scanning spot produced highly localized activation consistent with bipolar-cell engagement via temperature-sensitive ion channels. In vivo, patterned stimulation elicited visual cortex electrocorticogram responses in both wild-type and blind mice without systemic toxicity or significant retinal damage. This approach offers a less invasive, high-resolution, and broadly applicable pathway toward customizable vision restoration.</mods:abstract>
  <mods:name>
    <mods:namePart>Lee, Jonghwan</mods:namePart>
    <mods:role>
      <mods:roleTerm authority="marcrelator" authorityURI="http://id.loc.gov/vocabulary/relators" valueURI="http://id.loc.gov/vocabulary/relators/cre">Creator</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:originInfo>
    <mods:dateCreated>2025</mods:dateCreated>
  </mods:originInfo>
  <mods:subject authority="local">
    <mods:topic>Retinal prosthesis</mods:topic>
  </mods:subject>
  <mods:subject authority="local">
    <mods:topic>vision restoration</mods:topic>
  </mods:subject>
  <mods:subject authority="local">
    <mods:topic>gold nanorod</mods:topic>
  </mods:subject>
  <mods:subject authority="local">
    <mods:topic>near-infrared laser</mods:topic>
  </mods:subject>
  <mods:subject authority="local">
    <mods:topic>animal research</mods:topic>
  </mods:subject>
  <mods:genre>datasets</mods:genre>
<mods:note type="funding">This research is funded by the NIH National Eye Institute under award R01EY030569.</mods:note>
<mods:accessCondition xmlns:xlink="http://www.w3.org/1999/xlink" type="use and reproduction" xlink:href="https://www.gnu.org/licenses/gpl.txt">This work is licensed under a GNU GPL3 License</mods:accessCondition>
<mods:accessCondition xmlns:xlink="http://www.w3.org/1999/xlink" type="logo" xlink:href="https://www.gnu.org/graphics/gplv3-88x31.png"/>  
<mods:accessCondition type="rights statement" xlink:href="http://rightsstatements.org/vocab/InC/1.0/">In Copyright</mods:accessCondition>
  
<mods:identifier type="doi">10.26300/p63w-zj90</mods:identifier></mods:mods>