- Title Information
- Title
- Developing Biologically Relevant Artificial Substrates for Bioadhesive Testing
- Type of Resource (primo)
- dissertations
- Name:
Personal
- Name Part
- Lyakhovych, Zakhar
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Shukla, Anita
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Mathiowitz, Edith
- Role
- Role Term:
Text
- Advisor
- Name:
Personal
- Name Part
- Wong, Ian
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Biology and Medicine: Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Origin Information
- Copyright Date
- 2023
- Physical Description
- Extent
- vii, 25 p.
- digitalOrigin
- born digital
- Note:
thesis
- Thesis (Sc. M.)--Brown University, 2023
- Genre (aat)
- theses
- Abstract
- Bioadhesion, defined as the phenomena of adherence between natural tissue and
synthetic materials, is an important property with relevance in a wide range of biomedical fields
such as drug delivery and implantable devices. Understanding the bioadhesive properties of
polymers and how to control them has significant implications for both oral and topical drug
delivery. Current bioadhesive testing methods vary significantly across the field, utilizing a wide
range of approaches to studying several different aspects of bioadhesion. With macroscopic
drug delivery fracture theory is the dominant force and can be quantitatively measured.
Current approaches to testing fracture theory often use cadaver tissue. This has limitations with
viability, with tissue decomposition beginning almost immediately, and biological relevance,
with moisture and tissue-to-tissue variation creating high variability in readings. By creating an
artificial substrate that is meant to mimic a physiological environment, variability in bioadhesive
measurements can be consistently reduced and provide a comparison across runs that cadaver
tissue would not show as well as allowing extensive testing without the excessive use of ex-vivo
models.
- Subject
- Topic
- Polymer Films
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01070574")
- Topic
- Polymeric drug delivery systems
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00832578")
- Topic
- Biomedical engineering--Research
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01765101")
- Topic
- Polycaprolactone
- Subject
- Topic
- Bioadhesion
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/02000623")
- Topic
- Curcumin
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00858000")
- Topic
- Chitosan
- Subject
- Topic
- Ex Vivo
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01028612")
- Topic
- Mucins
- Language
- Language Term (ISO639-2B)
- English
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20230602